Contact Information:

Justin Legleiter


Phone: 304-293-0175

Welcome to the Legleiter Lab

The major research goal of our laboratory is to understand the molecular mechanisms that underlie neurodegenerative disorders associated with protein misfolding and aggregation, with a focus on Alzheimer’s disease (AD), Huntington’s disease (HD) and Parkinson’s disease (PD). In particular, we are interested in the potential role cellular and subcellular surfaces may play in these events.

Lab News

December 2019: Faezeh's paper, "SUMOylation Prevents Huntingtin Fibrillization and Localization onto Lipid Membranes," was published in ACS Chemical Neuroscience.

December 2019: Albert's paper, "Acetylation of Aβ40 Alters Aggregation in the Presence and Absence of Lipid Membranes," was published in ACS Chemical Neuroscience.

December 2019: Jim's paper, "Nucleation Inhibition of Huntingtin Protein (htt) by Polyproline PPII Helices: A Potential Interaction with the N-Terminal α-Helical Region of Htt," was published in Biochemistry.

November 2019: Maryssa contributed to an article, "Investigating the interactions of the first 17 amino acid residues of Huntingtin with lipid vesicles using mass spectrometry and molecular dynamics," published in the Journal of Mass Spectrometry.

October 2019: The lab published a highly collaborative project, "Lipid Membranes Influence the Ability of Small Molecules To Inhibit Huntingtin Fibrillization," in Biochemistry. This article was highlighted in the Biochemistry News Flash.

October 2019: Justin presented the lab's research at Edinboro University.

August 2019: Alyssa presented her research at the National Meeting of the American Chemical Society

July 2019: Katie presented her summer research at the WVU Undergraduate Summer Research Symposium.

June 2019: Congratulations to Dr. Albert Pilkington for successfully defending his dissertation.

June 2019: Albert's paper, "Hydrogen Peroxide Modifies Aß-Membrane Interactions with Implications for Aß40 Aggregation" was published in Biochemistry.

March 2019: The lab attend the 63rd Annual Meeting of the Biophysical Society in Baltimore, MD. Maryssa presented her research in a platform session. Faezeh, Sharon, Albert, and Adewale presented posters on their research. Faezeh was chosen to give a flash talk.


January 2019: Justin presented the lab's research at Ohio University.


January 2019: Albert's review article was published in AIMS Biophysics.


July 2018: Alyssa presented her research at the WVU Undergraduate Summer Research Symposium.


July 2018: Justin presented the lab's research at Anhui University in Heifei, China and at East China University of Science and Technology in Shanghai, China.

For older Lab News, click HERE

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